Fertility: Edited by Aydin AriciPreterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysisBromer, Jason Ga; Ata, Barisb; Seli, Meltemc; Lockwood, Charles Jd; Seli, Emrea Author Information aDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA bDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada cDivision of Neonatology, Department of Pediatrics, USA dDivision of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA Correspondence to Emre Seli, MD, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 300 George Street Suite 770J, New Haven, CT 06511, USA Tel: +1 203 7854018; e-mail: [email protected] Current Opinion in Obstetrics and Gynecology 23(3):p 168-173, June 2011. | DOI: 10.1097/GCO.0b013e32834551cd Buy Metrics Abstract Purpose of review Simultaneous transfer of multiple embryos in an assisted reproductive technology (ART) cycle results in a high rate of multiple pregnancy. Besides the medical complications associated with multiple pregnancy, the financial burden of the resultant preterm infants is also substantial. The current review evaluates the costs associated with the care of preterm infants that are born as a result of ART-associated multiple pregnancies. Recent findings In 2006, 30% of all ART live births were multiple infant deliveries in the USA. This resulted in 48% of all ART neonates being the product of a multiple infant delivery. In the same year, 62% of ART twins and 97% of ART triplets were delivered preterm, corresponding to approximately 17 000 infants. The Board of Health Sciences Policy has estimated the mean cost of each preterm infant to be US$ 51 600. Therefore, the financial burden of ART-associated preterm deliveries is estimated to be approximately US$ 1 billion annually. This figure has remained essentially unchanged between 2001 and 2006, despite decreasing number of embryos transferred, due to increasing total number of ART cycles performed. Summary Preterm deliveries that result from ART-associated multiple pregnancies add a substantial burden to overall US healthcare expenditure annually. Policies limiting the number of embryos transferred should be considered with a perspective to increase elective single embryo transfers. © 2011 Lippincott Williams & Wilkins, Inc.