Women's health: Edited by Gubby Ayida and Joseph AquilinaThromboembolism in pregnancy: recurrence risks, prevention and managementJames, Andra HAuthor Information Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA Correspondence to Andra H. James, MD, Box 3967 DUMC, Durham, NC 27710, USA Tel: +1 919 668 0011; fax: +1 919 681 7861; e-mail: email@example.com Current Opinion in Obstetrics and Gynecology: December 2008 - Volume 20 - Issue 6 - p 550-556 doi: 10.1097/GCO.0b013e328317a427 Buy SDC Metrics Abstract Purpose of review The purpose of this review is to summarize the epidemiology of thromboembolism in pregnancy and describe strategies to prevent and treat it. Recent findings The main reason for the increased risk of thrombosis in pregnancy is hypercoagulability. Other risk factors include a history of thrombosis, inherited and acquired thrombophilia, certain medical conditions, and complications of pregnancy and childbirth. Summary The hypercoagulability of pregnancy is present as early as the first trimester and so is the increased risk of thrombosis. Candidates for anticoagulation are women with a current thrombosis, a history of thrombosis, thrombophilia and a history of poor pregnancy outcome, or risk factors for postpartum thrombosis. For fetal reasons, the preferred agents for anticoagulation in pregnancy are heparins. There are no large trials of anticoagulants in pregnancy and recommendations are based on case series and the opinion of experts. Nonetheless, anticoagulants are believed to improve the outcome of pregnancy for women and their fetuses. © 2008 Lippincott Williams & Wilkins, Inc.