Fertility: Edited by Aydin AriciTraditional Chinese medicine and infertilityHuang, Sheng-Tenga,b; Chen, Annie Pei-ChunbAuthor Information aDepartment of Chinese Medicine, Chang Gung Memorial Hospital– Kaohsiung Medical Center, Chang Gung Institute of Technology, Taiwan, ROC bDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA Correspondence to Dr Sheng-Teng Huang MD, PhD, Department of Chinese Medicine, Chang Gung Memorial Hospital– Kaohsiung Medical Center, Chang Gung Institute of Technology, Taiwan, ROC Tel: +886 7 7317123 ext. 2334; fax: +886 7 7317123 ext. 2335; e-mail: [email protected] Current Opinion in Obstetrics and Gynecology: June 2008 - Volume 20 - Issue 3 - p 211-215 doi: 10.1097/GCO.0b013e3282f88e22 Buy Metrics Abstract Purpose of review The present review gives an overview of the potential use of traditional Chinese medicine in the treatment of infertility, including an evidence-based evaluation of its efficacy and tolerance. Recent findings Recent studies demonstrated that traditional Chinese medicine could regulate the gonadotropin-releasing hormone to induce ovulation and improve the uterus blood flow and menstrual changes of endometrium. In addition, it also has impacts on patients with infertility resulting from polycystic ovarian syndrome, anxiety, stress and immunological disorders. Although study design with adequate sample size and appropriate control for the use of traditional Chinese medicine is not sufficient, the effective studies have already indicated the necessity to explore the possible mechanisms, that is, effective dose, side effect and toxicity of traditional Chinese medicine, in the treatment of infertility by means of prospective randomized control trial. Summary The growing popularity of traditional Chinese medicine used alone or in combination with Western medicine highlights the need to examine the pros and cons of both Western and traditional Chinese medicine approaches. Integrating the principle and knowledge from well characterized approaches and quality control of both traditional Chinese medicine and Western medical approaches should become a trend in existing clinical practice and serve as a better methodology for treating infertility. © 2008 Lippincott Williams & Wilkins, Inc.