Reproductive endocrinologyElective oophorectomy in the gynecological patient: when is it desirable?Parker, William Ha; Shoupe, Donnab; Broder, Michael Sa; Liu, Zhimeic; Farquhar, Cindyd; Berek, Jonathan Se Author Information aUCLA School of Medicine, Los Angeles, California, USA bUSC School of Medicine, Columbia, South Carolina, USA cCerner Health Insights, Beverley Hills, California, USA dUniversity of Auckland School of Medicine, Auckland, New Zealand eStanford School of Medicine, Stanford, California, USA Correspondence to William H. Parker, MD, 1450 Tenth Street, Santa Monica, CA 90401, USA Tel: +1 310 451 8144; fax: +1 310 451 3414; e-mail: [email protected] Current Opinion in Obstetrics and Gynecology: August 2007 - Volume 19 - Issue 4 - p 350-354 doi: 10.1097/GCO.0b013e32821642d1 Buy Metrics Abstract Purpose of review Oophorectomy is electively performed in approximately 300 000 US women per year who are having hysterectomy for benign disease. Recent findings New studies have suggested that elective oophorectomy may not be advisable for the majority of women, as it may lead to a higher risk of death from cardiovascular disease and hip fracture, and may result in a higher incidence of dementia and Parkinson's disease. Women with known BRCA 1/2 germ-line mutations clearly benefit from oophorectomy after childbearing. Summary Prophylactic oophorectomy should be undertaken with caution in the majority of women with an average risk of ovarian cancer who are having a hysterectomy for benign disease. Abbreviations CHD: coronary heart disease; WHI: Women's Health Initiative. © 2007 Lippincott Williams & Wilkins, Inc.