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Reproductive outcomes after in-vitro fertilization

Mukhopadhaya, Neelanjanaa; Arulkumaran, Sabaratnamb

Current Opinion in Obstetrics and Gynecology: April 2007 - Volume 19 - Issue 2 - p 113–119
doi: 10.1097/GCO.0b013e32807fb199
Maternal-fetal medicine

Purpose of review This paper reviews the effect of in-vitro fertilization on maternal and perinatal outcomes of pregnancy.

Recent findings Few randomized, controlled trials have been published in this area due to inherent difficulties in studying this population of infertile women who require in-vitro fertilization. Systematic review of the literature identified published studies that consistently highlighted the higher incidence of maternal and perinatal morbidity associated with pregnancies following in-vitro fertilization.

Summary Some prospective observational studies compare maternal and perinatal outcomes in in-vitro fertilization pregnancies. Larger studies show that adverse pregnancy outcomes such as preeclampsia, gestational hypertension, placental abruption, placenta praevia, and preterm delivery increase significantly with in-vitro fertilization. Perinatal adverse outcomes such as prematurity and those related to plurality of the pregnancy also increase. All patients undergoing in-vitro fertilization should have careful counselling regarding these increased risks prior to treatment.

aSt Georges Hospital, United Kingdom

bSt Georges Medical School, University of London, London, United Kingdom

Correspondence to Neelanjana Mukhopadhaya, MBBS, DGO, MRCOG, Specialist Registrar in Obstetrics and Gynaecology, 3rd Floor, Lanesborough Wing, St Georges Hospital, Blackshaw Road, Tooting, London SW17 0QT Tel: +0208 725 5956; fax: +0208 725 5958; e-mail:

© 2007 Lippincott Williams & Wilkins, Inc.