Review ArticleRole of routine human papillomavirus subtyping in cervical screeningGoodman, AnnekathrynAuthor Information Division of Gynecologic Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA Correspondence to Annekathryn Goodman, MD, Massachusetts General Hospital, WACC 231, Boston, MA 02114, USA. Tel: +1 617 726 2429; fax: +1 617 724 0257; e-mail: email@example.com Current Opinion in Obstetrics and Gynecology: February 2000 - Volume 12 - Issue 1 - p 11-14 Buy SDC Abstract Human papillomavirus testing has been evaluated as an adjunct to cervical cytologic screening. There is a well-established association between high-risk malignant subtypes of human papillomavirus infection and the development of neoplastic change. Although human papillomavirus infection is a necessary condition for malignant transformation, it is not a sufficient condition. Multiple cofactors are necessary for progression to dysplasia and then to invasive cervical cancer. Because of the multifactorial nature of malignant transformation, current methods of human papillomavirus testing do not add sufficient predictive and diagnostic information over that obtained by cytology and colposcopic biopsy to warrant routine clinical use. © 2000 Lippincott Williams & Wilkins, Inc.