Headache: Edited by Hans-Christoph DienerTrigeminal autonomic cephalalgias: diagnostic and therapeutic developmentsGoadsby, Peter Ja,b; Cittadini, Elisabettab; Burns, Brianb; Cohen, Anna SbAuthor Information aHeadache Group, Department of Neurology, University of California, San Francisco, San Francisco California, USA bInstitute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK Correspondence to Professor Peter J. Goadsby, Headache Group, Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0114, USA E-mail: [email protected] Current Opinion in Neurology: June 2008 - Volume 21 - Issue 3 - p 323-330 doi: 10.1097/WCO.0b013e3282fa6d76 Buy Metrics Abstract Purpose of review The review was designed to summarize recent research relevant to the trigeminal autonomic cephalalgias, which include cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing/cranial autonomic features (SUNCT/SUNA). Hemicrania continua is included for completeness. Recent findings Cluster headache has the longest attack duration and relatively low attack frequency. Paroxysmal hemicrania has intermediate duration and intermediate attack frequency. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing have the shortest attack duration and the highest attack frequency. Hemicrania continua has a continuous pain with exacerbations that can include cranial autonomic symptoms as part of the phenotype. The importance of diagnosing these syndromes resides in their excellent but highly selective response to treatment. Summary Considerable advances have been made in the diagnostic and therapeutic approaches to trigeminal autonomic cephalalgias and these are important for neurologists to consider. © 2008 Lippincott Williams & Wilkins, Inc.