HEADACHE AND THE PERSON WITH INTRACRANIAL HYPERTENSION
Headache in IIH is known to have a detrimental effect on quality of life [8,9] and chronic headaches have a profound effect on people's lives, showing similarities with other pain conditions . The Idiopathic Intracranial Hypertension Treatment Trial (IIHTT), a key trial, was a North American multicentre, double-blind, randomised, placebo-controlled study of 165 participants with investigating utility of acetazolamide in mild visual loss . In this cohort, headache, particular when associated with photophobia, was the major factor in detrimental general and visual quality of life [9,14▪▪].
In an observational study, headache frequency and severity of depression symptoms were independent predictors of disability in IIH with mean score of 22.8 (±15.2), compared with an average Italian general population of 12.9. This indicated that consideration should be given to reducing headache and treating depression in IIH . In the United Kingdom, the James Lind Alliance priority setting partnership investigated over 500 IIH patients and clinician preferences, understanding of headache mechanisms and treatment was ranked in two domains of the top 10 research priorities for IIH. This reflects the unmet need of the disability of headache in everyday life of our patients [16▪].
PHENOTYPING INTRACRANIAL HYPERTENSION-RELATED HEADACHE
Historically, a raised ICP headache is positional, with nocturnal awakening, worse on waking and aggravated by Valsalva manoeuvre. Studies now have classified those with headache and IIH would meet the International Headache Society criteria  as having either episodic migraine, chronic migraine or tension-type headache (Table 1). According to the IIHTT, the quality of the pain was pressure-like in 47% and throbbing in 42% [14▪▪], which is similar to migraine . Photophobia, phonophobia, nausea, vomiting and worsening on physical activity were reported and none of these migraine features separated IIH headache from migraine [14▪▪]. Other symptoms included constant visual loss; transient visual obscurations, diplopia and dizziness; these could help distinguish primary migraine from migraine in IIH; however, the authors cautioned that 14% with headache and papilloedema had none of these associated symptoms [14▪▪] (Table 2).
In children with pseudotumour cerebri (PSTC), Lee et al.[18▪] studied the difference in children's drawings of their headaches. A total of 21 children with PSTC and 518 children with migraine showed that drawings had similar features except one-third (28.6%) with PSTC depicted diplopia which was highly significant (P = 0.00001). Diplopic images may serve as a useful ‘red flag’ for those who investigate children for raised ICP.
PRIOR HISTORY AND FAMILY HISTORY OF HEADACHE
Prior history of headache in the IIHTT was found in 41% [14▪▪], which is similar to Yri et al. who found in 45% of their IIH cohort with 25% having prior migraine and 34% having prior tension-type headaches. This is nearly double that of the US female population with 18% having history of migraine . Positive family history was high, with one study reporting up to 68% of those with IIH . These factors may be implicated in the pathophysiology of headache in IIH. What is of importance is the re-examination for papilloedema in those who have a change or escalation in their headache .
HEADACHE OUTCOMES IN INTRACRANIAL HYPERTENSION STUDIES
Overall, there are few studies investigating headache; they report different headache outcomes and have a small number of patients (Table 1), and the results of which are not surprisingly conflicting in this rare disease.
HEADACHE SEVERITY AND FREQUENCY
Headache severity in IIH appears to be moderate to severe. In the Birmingham prospective study investigating women with IIH who followed a low-calorie diet for 3 months, severity, as recorded using the visual analogue pain score, was 4.2 (±2.8) and reduced to 1.9 (±2.8), P = 0.015, at study end with significantly reduced ICP compared with pressure measured in the 3 months before the diet . Others have reported higher severity of 5.6 (±2.5) , and the IIHTT baseline headache severity was 6.3 (±1.9) on a 0–10 scale, with 5.4% reporting 10/10 . Differences could exist because of duration of IIH and medication overuse headache.
Headache frequency in IIH is typically episodic in new onset disease and chronic in more longstanding disease (Table 1). Both severity and frequency have not appeared to correlate with lumbar puncture opening pressure in the IIHTT [14▪▪], and the portions between episodic and chronic could reflect time to enrolment from diagnosis, or onset of raised ICP, or existence of other coexisting headache phenotypes.
HEADACHE DISABILITY SCORE
The Headache Impact Test (HIT)-6 , which is a validated for use across headache disorders, is commonly used . Most agree at baseline the HIT-6 measures substantial to severe impact on IIH patients. Headache disability is multifactorial, and comorbid conditions can influence disability for example those with a high risk of sleep apnoea, as determined by the Berlin questionnaire, had a higher HIT-6 score in the IIHTT (P = 0.04) [14▪▪].
In the Birmingham weight loss study , baseline HIT-6 was 57.5 (±9.0) which significantly improved after weight loss to 46.9 (±10.1) (P = 0.004). The IIHTT HIT-6 mean baseline was similar to 59.7 (±9.0) reducing both arms by over 9 points, which did not reach significance [14▪▪]. In an open-label extension of the IIHTT , 96 participants were sorted into remaining on acetazolamide (n = 34), switch placebo to acetazolamide (n = 35), switch acetazolamide to no treatment (n = 16) and switch placebo to no treatment (n = 11). At month 12, those switched placebo to acetazolamide had significant improvement HIT-6 with −3.70 point reduction (P = 0.01). This is an interesting fact; however, caution must be used in interpreting this as headache outcomes are prone to placebo effects and total blinding to treatment allocation is hampered by knowledge of trial arm allocation and through the experience of drug-related side-effects (such as use of acetazolamide and experiencing paraesthesia) .
HEADACHE RELATIONSHIP TO INTRACRANIAL PRESSURE
The relationship between headache and degree of ICP elevation is not fully delineated and is likely to be complicated. Younger age (P = 0.03) of onset and high lumbar puncture opening pressure (P = 0.03) have both been associated with better odds of being without headache or with only infrequent headache (<1 day/month) headache after 12 months .
Amongst IIHTT cohort, there was no relationship found between the mean lumbar puncture opening pressure, 343.5 (±86.9) and the presence or absence of headache at baseline [14▪▪]. This potentially suggests an individual threshold of tolerance of differing degrees of ICP and that once elevated other factors may contribute to chronicity. Analogies maybe drawn to posttraumatic headache in which susceptibility is influenced by previous migraine history, childhood migraine and family history of migraine, potentially suggesting an underlying genetic predisposition to headache and not necessarily a clear correlation between degree of trauma. Other investigators have supported theories that headache in IIH is attributed to more complex mechanisms than ICP elevation alone .
The IIHTT highlighted that there was no statistical relationship found between headache severity (0–10 scale) and ICP, at both baseline and trial end. Only half agreed to have a lumbar puncture at 6 months (65 had headache and 20 without) and there was no correlation between HIT-6 and lumbar puncture opening pressure (r = 0.12; P = 0.29), but the number of headache days weakly correlated (r = 0.12, P = 0.04). Lumbar puncture opening pressure changed by 112.3 mm cerebrospinal fluid (CSF) in the acetazolamide group and 52.4 mm CSF in the placebo group (P = 0.002) and both arms reported headaches (69% acetazolamide and weight loss arm; 68% placebo and weight loss arm) [14▪▪].
In the Birmingham weight loss study, lumbar puncture opening pressure was 38.0 (±5.0) at the start of the diet and 30.0 (±4.9) (P < 0.001). HIT-6 significantly improved with this reduction in ICP (P = 0.004) and there were significant improvements, by greater than 50%, in headache severity (visual analogue pain score (0–10) from 4.2 (±2.8) to 1.9 (±2.8), (P = 0.015), headache frequency from 4.4 (±2.9) to 2.1 (±2.8) days a week (P = 0.011), and weekly use of analgesics from 2.2 (±2.5) to 0.2 (±0.4) days a week (P = 0.007). Patients’ symptoms (headache, tinnitus, obscurations and diplopia) showed significant improvement after the low energy diet (P < 0.001, P = 0.004, P = 0.025 and P = 0.008, respectively) One explanation of the difference between this study  and IIHTT [14▪▪], in which the magnitude CSF pressure reduction was similar, may be that the Birmingham study assessed the intervention at 3 months, compared with 6 months in the IIHTT.
In children with IIH, Hamedani et al.[28▪] retrospectively reported headache characteristics. They detailed headache pattern from clinical records, severity (subjectively determined) and location along with associated symptoms of visual change and nausea. There was no difference between the groups in terms of pain severity, and presence of nausea, despite there being distinct differences in median lumbar puncture opening pressure between definite PTCS (39 cm CSF), probable PTCS (24 cm CSF), elevated opening pressure (35 cm CSF) and normal opening pressure group (23 cm CSF) (P < 0.001). It may be that once ICP is over a ‘patient specific threshold’ headache will occur, but the absolute degree of ICP elevation may not be the primary underlying mechanism.
MANAGEMENT OF HEADACHE IN INTRACRANIAL HYPERTENSION
The 2015 Cochrane review concluded that there is a lack of evidence to guide pharmacological treatment in IIH . There are few published randomised clinical trials [11,12] and a small number of ongoing trials [30,31]. None of these have focused on management of headache. Managing headache in IIH is an essential aspect of patient care and recent consensus guidelines have provided a practical approach to managing them [1▪▪].
MANAGEMENT OF MIGRAINE IN INTRACRANIAL HYPERTENSION
As migraine is the predominant phenotype (Table 1), the use of migraine therapies has been recommended [1▪▪]. Migraine attacks may benefit from triptan acute therapy used in combination with either a nonsteroidal anti-inflammatory or paracetamol and an antiemetic with pro-kinetic properties [32▪]. Their use should be limited to in the region of 2 days/week or a maximum of 10 days/month [32▪]. Where medication overuse coexists, this should be addressed, and if chronic migraine is present, preventive strategies have been recommended [1▪▪,33]. Caution should be observed before selecting drugs that could increase weight such as β-blockers, tricyclic antidepressants, sodium valproate, pizotifen and flunarizine. Care should be taken in those medications that exacerbate depression which is a frequent co-morbidity in IIH, such as β-blockers, topiramate and flunarizine [1▪▪].
A meta-analysis demonstrated that topiramate was effective in reducing headache frequency and was reasonably well tolerated in adult patients with episodic migraine [34▪]. It may have additional benefits of suppressing appetite and have an effect on reducing ICP through carbonic anhydrase inhibition. In-vivo studies demonstrated that both subcutaneous and oral administration of topiramate significantly lowered ICP in rodents, whereas other drugs tested, including acetazolamide, furosemide, amiloride and octreotide, did not significantly reduce ICP . Topiramate utility in IIH reported in an open-label study which randomly assigned 40 patients with IIH to acetazolamide or topiramate and demonstrated treatment equivalence with all experiencing improvement in visual fields .
Other preventive therapies, some of which are not licenced for migraine, could include candesartan because of its lack of weight gain and depressive side-effects  or potentially non-invasive neuromodulation . Botulinum toxin A, which is a licenced therapy for migraine, could also be useful in those with coexisting chronic migraine [39▪]. Other strategies, such as mindfulness, may suit some patients [40▪].
MANAGEMENT OF MEDICATION OVERUSE HEADACHE
One-third of IIHTT participants overused medication at baseline, on the basis of the last 30-day history, and had a significantly higher mean HIT-6 score (63.1 ± 6.9) than in those without (58.1 ± 9.4; P = 0.0007) [14▪▪]. Other studies found management of medication overuse headache (MOH) a more common issue for IIH patients long term, reflecting the study type . Successfully removing excessive analgesic use significantly improves headaches in other headache disorders. What is yet what is yet to be determined is the effects it has on the course of IIH-related headache . It seems prudent that all IIH patients with headaches are warned about avoiding excessive analgesic use and where MOH exists standard advice of removal given [41,42].
THERAPEUTIC LUMBAR PUNCTURE
Professional bodies in the United Kingdom [1▪▪] and Europe  do not advocate therapeutic lumbar puncture as a treatment strategy for IIH. Although lumbar puncture induces a transient reduction of ICP, the effect is typically short lived with pressure rising rapidly after the procedure . There is growing awareness regarding the morbidity of the procedure [45,46]. IIH patients frequently report a negative and emotional experience when they undergo a lumbar puncture [47,48] and the majority of active IIH patients (papilloedema and lumbar puncture opening pressure >25 cm CSF) will face an exacerbation of headache in the week following lumbar puncture . The long-term therapeutic effects of lumbar puncture are not well known.
NEUROSURGICAL TREATMENT OF HEADACHE
CSF shunting to exclusively treat headache in IIH has limited evidence. About 68% will continue to have headaches at 6 months and 79% by 2 years following CSF diversion. A third have been reported to develop iatrogenic low pressure headaches, although this figure may be lower depending on shunt and valve types . There is uncertainty that failure to optimise ICP may render the migraine headaches difficult to treat, and if headache was indicated for CSF shunting, then a period of ICP monitoring preoperatively may be useful to determine the success of the proposed procedure [1▪▪].
INTERVENTIONAL VASCULAR STENTING FOR HEADACHE
The literature detailing dural venous stenting typically does not clearly separate the cohorts of IIH into those with acute visual loss and those with headaches. Many case series are small, nonrandomised, do not detail morphological stenosis type and some do not record the pressure gradient. There are selection bias, differing treatment protocols, poor characterisation of headache phenotype and a lack of long-term follow-up . Additionally, objective validated headache outcome measures are infrequently utilised. Well characterised studies would be welcomed in this area.
MANAGEMENT OF HEADACHES IN THE SHUNTED PATIENT
Shunted patients may have significant headache morbidity and understanding the underlying causes may guide management. It has been recommended that shunt revision should not routinely be undertaken unless there is an assessment of vision for papilloedema and there is a risk of visual deterioration . There is little indication to perform shunt series, as they do not determine shunt failure or overdrainage or change management decisions . As with chronic headaches, removal of MOH [53,54] and migraine treatments should be considered; additionally, ICP monitoring may be informative to direct treatment choices [1▪▪].
Migraine phenotype and prior history of headache before a diagnosis of IIH needs to be recognised by clinicians to avoid misdiagnosis. There is an unmet need to treat headaches in IIH. Future studies should consider core outcome measures for headache, as used in migraine trials, which would optimise meta-analysis. Migraine abortive and preventive therapies can be used, but currently there is no high-class evidence to help guide treatment decisions.
Financial support and sponsorship
A.J.S. is funded by an NIHR Clinician Scientist Fellowship (NIHR-CS-011-028) and by the Medical Research Council, United Kingdom (MR/K015184/1).
Conflicts of interest
There are no conflicts of interest.
REFERENCES AND RECOMMENDED READING
Papers of particular interest, published within the annual period of review, have been highlighted as:
- ▪ of special interest
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Keywords:Copyright © 2019 Wolters Kluwer Health, Inc. All rights resereved.
headache; idiopathic intracranial hypertension; medication overuse headache; migraine; raised intracranial pressure