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A model of poststroke fatigue based on sensorimotor deficits

Kuppuswamy, Annapoornaa; Rothwell, Johna; Ward, Nicka,b,c

doi: 10.1097/WCO.0000000000000260
TRAUMA AND REHABILITATION: Edited by S. Thomas Carmichael

Purpose of review This review examines recent studies in poststroke fatigue that might contribute in understanding the pathophysiology of poststroke fatigue. Poststroke fatigue is a common problem in stroke survivors. Little is known about the pathophysiology of chronic fatigue in stroke survivors. It has long been thought of as a neuropsychiatric problem. However, there is gathering evidence to the contrary. In this study, we propose a new model of poststroke fatigue based on recent findings of corticomotor neurophysiological, behavioural, and perceptual deficits in the poststroke fatigue population.

Summary The current evidence suggests that poststroke fatigue may not be a neuropsychiatric problem but a problem of the sensorimotor system. Future studies need to address the causal link between sensorimotor deficits and poststroke fatigue.

aSobell Department of Motor Neuroscience, UCL Institute of Neurology

bThe National Hospital for Neurology and Neurosurgery

cUCLPartners Centre for Neurorehabilitation, London, UK

Correspondence to Annapoorna Kuppuswamy, Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Box 146, 4th floor Clinical Neurosciences building 33, Queen Square WC1N 3BG, London, UK. E-mail:

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