MUSCULAR DISEASE: Edited by John VissingThe increasing role of muscle MRI to monitor changes over time in untreated and treated muscle diseasesNuñez-Peralta, Claudiaa,b; Alonso-Pérez, Jorgec; Díaz-Manera, Jordic,d,eAuthor Information aRadiology Department, Hospital de la Santa Creu i Sant Pau bDepartament de Medicina, Universidad Autónoma de Barcelona cNeuromuscular Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain dJohn Walton Muscular Dystrophy Research Center, Newcastle University, Newcastle Upon Tyne, UK eCentro de investigación Biomédica en Red en Enfermedades Raras (CIBERER), Spain Correspondence to Jordi Díaz-Manera, John Walton Muscular Dystrophy Research Center, Newcastle University, Center for Life, Central Parkway, NE13BZ Newcastle Upon Tyne, UK. Tel: +44 191 241 8941; e-mail: [email protected] Current Opinion in Neurology: October 2020 - Volume 33 - Issue 5 - p 611-620 doi: 10.1097/WCO.0000000000000851 Buy Metrics Abstract Purpose of review This review aims to discuss the recent results of studies published applying quantitative MRI sequences to large cohorts of patients with neuromuscular diseases. Recent findings Quantitative MRI sequences are now available to identify and quantify changes in muscle water and fat content. These two components have been associated with acute and chronic injuries, respectively. Studies show that the increase in muscle water is not only reversible if therapies are applied successfully but can also predict fat replacement in neurodegenerative diseases. Muscle fat fraction correlates with muscle function tests and increases gradually over time in parallel with the functional decline of patients with neuromuscular diseases. There are new spectrometry-based sequences to quantify other components, such as glycogen, electrolytes or the pH of the muscle fibre, extending the applicability of MRI to the study of several processes in neuromuscular diseases. Summary The latest results obtained from the study of long cohorts of patients with various neuromuscular diseases open the door to the use of this technology in clinical trials, which would make it possible to obtain a new measure for assessing the effectiveness of new treatments. The challenge is currently the popularization of these studies and their application to the monitoring of patients in the daily clinic. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.