DEGENERATIVE AND COGNITIVE DISEASES: Edited by Jean-Jean-François DemonetQuantitative MRI markers in Parkinson's disease and parkinsonian syndromesArribarat, Germain; Péran, PatriceAuthor Information ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, INSERM, UPS, Toulouse, France Correspondence to Patrice Péran, UMR 1214 – INSERM/UPS – ToNIC, Toulouse NeuroImaging Center, CHU PURPAN – Pavillon Baudo – Place du Dr Baylac, 31024 Toulouse Cedex 3, France. Tel: +33 05 62 74 61 64; e-mail: [email protected] Current Opinion in Neurology: April 2020 - Volume 33 - Issue 2 - p 222-229 doi: 10.1097/WCO.0000000000000796 Buy Metrics Abstract Purpose of review In Parkinson's disease and parkinsonian disorders, the differential diagnosis is still challenging. We aim to review current developments in MRI quantitative markers and their potential in a clinical and neuroscientific setting. Recent findings There have been efforts to improve MRI acquisition methods and to explore new promising biomarkers. In parallel, technological advances in data analysis (i.e. deep learning) open new ways to use these biomarkers. The MRI markers may differ according to the brain structure investigated. Even if the newly adopted acquisition protocols served mainly the development of brainstem-related biomarkers (neuromelanin MRI, nigrosome sensitive MRI), more established markers (e.g. morphometric values) in basal ganglia, cortex and cerebellum demonstrate their relevance especially to differential diagnosis in parkinsonian syndromes. Summary We provide an overview on recent advances in MRI quantitative markers of Parkinson's disease that we divide for didactic purposes in three anatomical levels – cortical/cerebellum structures, basal ganglia and brainstem. We show the complementarity of new biomarkers sensitive to brain tissue properties to established morphometrics. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.