Purpose of review
The purpose of this review is to discuss how a new treatment modality, tumor treating fields
, may be incorporated into the oncologic care for patients with glioblastoma
Recent findings Tumor treating fields
are a new treatment modality available to patients with newly diagnosed and recurrent glioblastoma
. Alternating electric fields are delivered via a wearable, removable device affixed to the scalp of patients with supratentorial glioblastoma
. With continuous use, the application of tumor treating fields
combined with temozolomide chemotherapy has been shown to improve overall survival compared with temozolomide alone in patients with newly diagnosed glioblastoma
. Adverse events attributable to the device are limited to localized skin reactions. Despite compendium guidelines in support of its use and Food and Drug Administration (FDA) approval, tumor treating fields
have been slow to be adopted in the neuro-oncology community. Critics have raised concerns about the generalizability of the study data, patient quality of life, and mechanism of action of this therapy.
Summary Tumor treating fields
are available for the treatment of both newly diagnosed and recurrent glioblastoma
and represent a new category of treatment modalities in oncologic therapy. This novel device has received FDA approval but has been slow to be adopted into clinical practice.