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The changing course of multiple sclerosis

rising incidence, change in geographic distribution, disease course, and prognosis

Magyari, Melinda; Sorensen, Per Soelberg

Current Opinion in Neurology: June 2019 - Volume 32 - Issue 3 - p 320–326
doi: 10.1097/WCO.0000000000000695
DEMYELINATING DISEASES: Edited by Hans-Peter Hartung

Purpose of review This review provides a brief update of new research findings on the changing epidemiology, disease course, and prognosis of multiple sclerosis (MS).

Recent findings Evidence not only continues to support the female predominance in incidence and prevalence of the disease but also supports an increase in incidence of MS in geographic areas that were previously considered to be low incidence for the disease.

Summary An increased interest in population-based registries and databases will provide more valid epidemiological measures and observational studies conducted in well-defined study populations. Such studies are crucial for an accurate description of both changing prognosis of MS and differential characteristics of the various MS phenotypes.

Department of Neurology, Danish Multiple Sclerosis Center and the Danish Multiple Sclerosis Registry, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark

Correspondence to Per Soelberg Sorensen, MD, DMSc, Department of Neurology 2082, Danish Multiple Sclerosis Center, Rigshospitalet, DK-2100 Copenhagen, Denmark. Tel: +45 3545 2080; e-mail:

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