DEMYELINATING DISEASES: Edited by Hans-Peter HartungThe changing course of multiple sclerosis: rising incidence, change in geographic distribution, disease course, and prognosisMagyari, Melinda; Sorensen, Per SoelbergAuthor Information Department of Neurology, Danish Multiple Sclerosis Center and the Danish Multiple Sclerosis Registry, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark Correspondence to Per Soelberg Sorensen, MD, DMSc, Department of Neurology 2082, Danish Multiple Sclerosis Center, Rigshospitalet, DK-2100 Copenhagen, Denmark. Tel: +45 3545 2080; e-mail: email@example.com Current Opinion in Neurology: June 2019 - Volume 32 - Issue 3 - p 320-326 doi: 10.1097/WCO.0000000000000695 Buy Metrics Abstract Purpose of review This review provides a brief update of new research findings on the changing epidemiology, disease course, and prognosis of multiple sclerosis (MS). Recent findings Evidence not only continues to support the female predominance in incidence and prevalence of the disease but also supports an increase in incidence of MS in geographic areas that were previously considered to be low incidence for the disease. Summary An increased interest in population-based registries and databases will provide more valid epidemiological measures and observational studies conducted in well-defined study populations. Such studies are crucial for an accurate description of both changing prognosis of MS and differential characteristics of the various MS phenotypes. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.