Management of chronic inflammatory demyelinating polyradiculopathyDoneddu, Pietro E.; Nobile-Orazio, EduardoCurrent Opinion in Neurology: October 2018 - Volume 31 - Issue 5 - p 511–516 doi: 10.1097/WCO.0000000000000595 PERIPHERAL NERVE AND NEURO-MUSCULAR JUNCTION DISEASE: Edited by Eduardo Nobile-Orazio Abstract Author InformationAuthors Article MetricsMetrics Purpose of review To review the recent advances in the management and treatment of chronic inflammatory demyelinating polyradiculopathy (CIDP). Recent findings Recent studies confirm the efficacy/safety of long-term intravenous immunoglobulin (IVIg) and short-term subcutaneous immunoglobulin (SCIg) therapy in CIDP. New outcome measures have been recently proposed and further studies evaluated the properties of those already in use. The presence of antibodies against proteins at the node of Ranvier was associated with specific clinical features and treatment response. Fingolimod adds to the list of immunosuppressive agents that failed to be effective in a controlled trial. Summary Several studies evaluating the best strategy to provide maintenance IVIg treatment in CIDP are in progress. SCIg were shown to be an alternative to IVIg for maintenance treatment while their efficacy as initial therapy should be further addressed. New outcome measures have been shown to be effective in detecting treatment response in clinical trials, but their use in clinical practice remains uncertain. Similarly unsettled is the role of nerve imaging techniques as biomarker in CIDP. The discovery of antibodies against proteins at the node of Ranvier has rekindled a keen interest in the pathogenesis of CIDP and the potential therapeutic role of new agents. Neuromuscular and Neuroimmunology Service, Humanitas Clinical and Research Center, Department of Medical Biotechnology and Translational Medicine, Milan University, Milan, Italy Correspondence to Eduardo Nobile-Orazio, Neuromuscular and Neuroimmunology Service, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan 20089, Italy. Tel: +390282242209; fax: +390282242298; e-mail: firstname.lastname@example.org Copyright © 2018 Wolters Kluwer Health, Inc. All rights resereved.