MOVEMENT DISORDERS: Edited by Marie VidailhetMovement disorders in mitochondrial disease: a clinicopathological correlationFlønes, Irene H.a,b; Tzoulis, Charalamposa,b Author Information aDepartment of Clinical Medicine, University of Bergen bDepartment of Neurology, Haukeland University Hospital, Bergen, Norway Correspondence to Charalampos Tzoulis, MD, PhD, Department of Neurology, Haukeland University Hospital, 5021 Bergen, Norway. Tel: +47 55975061; e-mails: [email protected]; e-mail: [email protected] Current Opinion in Neurology 31(4):p 472-483, August 2018. | DOI: 10.1097/WCO.0000000000000583 Buy Metrics Abstract Purpose of review The scope of this review is to give an updated account of movement disorders associated with mitochondrial disease, with a particular focus on recently discovered clinicopathological correlations. Recent findings Movement disorders are common clinical manifestations of mitochondrial diseases, in part because of the high vulnerability of neurons controlling motor circuits to mitochondrial respiratory dysfunction and energy failure. Intriguingly, the clinicopathological correlations of movement disorders in mitochondrial disease do not always conform to established neurophysiological knowledge. In particular, nearly complete substantia nigra degeneration and nigrostriatal denervation can occur without being accompanied by any of the clinical signs traditionally associated with parkinsonism. This apparent paradox, may be because of compensation by concomitant impairment of other motor circuits involving the cerebellum and thalamus. Summary Movement disorders commonly accompany mitochondrial disease and may show paradoxical clinical−anatomical correlations. Further research is warranted in order to elucidate the mechanisms underlying the phenotypic expression of movement disorders in mitochondrial disease. This knowledge will advance our understanding of the pathogenesis of movement disorders in a broader clinical and pathophysiological context. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.