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Closure of patent foramen ovale in cryptogenic stroke: a never ending story

Calvet, David; Mas, Jean-Louis


In the article by Calvet and Mas in issue 1, 2014 [1] , Table 4 was published incorrectly. The correct Table is shown below. The publisher apologises for this error.

Current Opinion in Neurology. 27(2):242, April 2014.

doi: 10.1097/WCO.0000000000000052

Purpose of review This review discusses current evidence on patent foramen ovale (PFO) closure compared with medical therapy alone in the prevention of stroke recurrence in patients with a PFO-associated cryptogenic stroke.

Recent findings The Risk of Paradoxical Embolism group built a 10-point Score, based on clinical parameters, that estimates the probability of finding a PFO in a patient with cryptogenic stroke and the probability that a PFO discovered in the setting of cryptogenic stroke is related to stroke vs. incidental.

Three recent randomized clinical trials failed to demonstrate the superiority of PFO closure over medical treatment alone in preventing stroke recurrence in patients aged 18–60 years who have had a cryptogenic stroke or transient ischemic attack.

Summary Stronger evidence in favor of PFO closure is needed before recommending this procedure outside of a clinical trial. Results of ongoing trials are much awaited.

Paris Descartes University, Centre de Psychiatrie et Neurosciences INSERM UMR 894 and Department of Neurology, Centre Hospitalier Sainte-Anne, Paris, France

Correspondence to Professor Jean-Louis Mas, Service de Neurologie, Hôpital Sainte-Anne, 1 rue Cabanis, 75674 Paris Cedex 14, France. Tel: +33 1 45 65 82 84; fax: +33 1 45 65 87 94; e-mail:

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins