Headache: Edited by Peter GoadsbyAn update on the blood vessel in migraineBrennan, KC; Charles, Andrew Author Information Department of Neurology, David Geffen School of Medicine at UCLA, California, USA Correspondence to K.C. Brennan, 635 Charles E. Young Drive South, Neuroscience Research Building, Room 555a, Los Angeles, CA 90095, USA Tel: +1 310 206 7226; e-mail: [email protected] Current Opinion in Neurology: June 2010 - Volume 23 - Issue 3 - p 266-274 doi: 10.1097/WCO.0b013e32833821c1 Buy Metrics Abstract Purpose of review The cranial blood vessel is considered an integral player in the pathophysiology of migraine, but its perceived role has been subject to much discussion and controversy over the years. We will discuss the evolution in our scientific understanding of cranial blood vessels (primarily arteries) in migraine. Recent findings Recent developments have clarified the role of cranial blood vessels in the trigemino-vascular system and in cortical spreading depression. An underlying theme is the intimate relation between vascular activity and neural function, and we will emphasize the various roles of the blood vessel that go beyond delivering blood. We conclude that migraine cannot be understood, either from a research or clinical point of view, without an understanding of the vascular derangements that accompany it. Summary Migraine is accompanied by significant derangements in vascular function that may represent important targets for investigation and treatment. © 2010 Lippincott Williams & Wilkins, Inc.