Trauma and rehabilitation: Edited by Nick WardBrain–computer interface in paralysisBirbaumer, Nielsa,b; Murguialday, Ander Ramosa,c; Cohen, LeonardodAuthor Information aInstitute of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, Germany bIRCCS Ospedale San Camillo, Istituto di Ricovero e Cura a Carattere Scientifico, Venezia Lido, Italy cFatronik Foundation, San Sebastian, Spain dHuman Cortical Physiology Section, and Stroke Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, USA Correspondence to Niels Birbaumer, PhD, Institute of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, Gartenstrasse 29, D-72074 Tuebingen, Germany Tel: +49 7071 2974219; e-mail: [email protected] Current Opinion in Neurology: December 2008 - Volume 21 - Issue 6 - p 634-638 doi: 10.1097/WCO.0b013e328315ee2d Buy Metrics Abstract Purpose of review Communication with patients suffering from locked-in syndrome and other forms of paralysis is an unsolved challenge. Movement restoration for patients with chronic stroke or other brain damage also remains a therapeutic problem and available treatments do not offer significant improvements. This review considers recent research in brain–computer interfaces (BCIs) as promising solutions to these challenges. Recent findings Experimentation with nonhuman primates suggests that intentional goal directed movements of the upper limbs can be reconstructed and transmitted to external manipulandum or robotic devices controlled from a relatively small number of microelectrodes implanted into movement-relevant brain areas after some training, opening the door for the development of BCI or brain–machine interfaces in humans. Although noninvasive BCIs using electroencephalographic recordings or event-related-brain-potentials in healthy individuals and patients with amyotrophic lateral sclerosis or stroke can transmit up to 80 bits/min of information, the use of BCIs – invasive or noninvasive – in severely or totally paralyzed patients has met some unforeseen difficulties. Summary Invasive and noninvasive BCIs using recordings from nerve cells, large neuronal pools such as electrocorticogram and electroencephalography, or blood flow based measures such as functional magnetic resonance imaging and near-infrared spectroscopy show potential for communication in locked-in syndrome and movement restoration in chronic stroke, but controlled phase III clinical trials with larger populations of severely disturbed patients are urgently needed. © 2008 Lippincott Williams & Wilkins, Inc.