Neuroimaging: Edited by Louis LemieuxResting-state functional connectivity in neuropsychiatric disordersGreicius, MichaelAuthor Information Stanford University School of Medicine, Neurology and Neurological Sciences, Stanford, California, USA Correspondence to Michael Greicius, MD, MPH, Stanford University School of Medicine, Neurology and Neurological Sciences, 300 Pasteur Drive, Rooom A343, Stanford, CA 94305-5235, USA E-mail: [email protected] Current Opinion in Neurology: August 2008 - Volume 21 - Issue 4 - p 424-430 doi: 10.1097/WCO.0b013e328306f2c5 Buy Metrics Abstract Purpose of review This review considers recent advances in the application of resting-state functional magnetic resonance imaging to the study of neuropsychiatric disorders. Recent findings Resting-state functional magnetic resonance imaging is a relatively novel technique that has several potential advantages over task-activation functional magnetic resonance imaging in terms of its clinical applicability. A number of research groups have begun to investigate the use of resting-state functional magnetic resonance imaging in a variety of neuropsychiatric disorders including Alzheimer's disease, depression, and schizophrenia. Although preliminary results have been fairly consistent in some disorders (for example, Alzheimer's disease) they have been less reproducible in others (schizophrenia). Resting-state connectivity has been shown to correlate with behavioral performance and emotional measures. It's potential as a biomarker of disease and an early objective marker of treatment response is genuine but still to be realized. Summary Resting-state functional magnetic resonance imaging has made some strides in the clinical realm but significant advances are required before it can be used in a meaningful way at the single-patient level. © 2008 Lippincott Williams & Wilkins, Inc.