Review ArticleTuberous sclerosis complexSparagana, Steven P.; Roach, E. Steve Author Information Texas Scottish Rite Hospital for Children and University of Texas Southwestern Medical School, Dallas, TX 75219, USA Correspondence to Steven P. Sparagana, MD, Department of Neurology, Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA. Tel: +1 214 559 7828; fax: +1 214 456 6108 (Dr Roach); e-mail: [email protected] Abbreviations CT: computerized tomography LOH: loss of heterozygosity MMPH: multifocal micronodular pneumocyte hyperplasia MRI: magnetic resonance imaging SEGA: subependymal giant cell astrocytoma TSC: tuberous sclerosis complex Current Opinion in Neurology: April 2000 - Volume 13 - Issue 2 - p 115-119 Buy Abstract Tuberous sclerosis complex is an autosomal dominant disorder that causes significant complications in multiple organ systems. Both basic science and clinical research on tuberous sclerosis complex have flourished in recent years, improving our understanding of its molecular genetics and pathophysiology. Two tuberous sclerosis complex genes cause nearly identical phenotypes, and great progress has been made towards understanding how each of these genes functions. The recognition of tuberous sclerosis complex improved with revised diagnostic criteria, and the management of many of the complications of tuberous sclerosis complex has improved. © 2000 Lippincott Williams & Wilkins, Inc.