Review ArticleGenetics of primary headachesKors, Esther E.a; Haan, Joostab; Ferrari, Michel D.a Author Information aDepartment of Neurology, Leiden University Medical Centre, Leiden, and bDepartment of Neurology, Rijnland Hospital, Leiderdorp, The Netherlands Correspondence to M.D. Ferrari, MD, PhD, Department of Neurology, K5Q, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands Tel: +31 (0) 71 5261641; fax: +31 (0) 71 5248253 Abbreviations FHM: Familial hemiplegic migraine MELAS: mitochondrial encephalomyopathy - lactic acidosis - stroke-like : episodes TTH: tension-type headache Current Opinion in Neurology: June 1999 - Volume 12 - Issue 3 - p 249-254 Buy Abstract Migraine has become an important topic in the field of complex genetic disorders. The identification of a gene on chromosome 19p encoding for an alpha 1A calcium channel subunit causing familial hemiplegic migraine has led to the classification of migraine as a channelopathy. More recently, efforts have been made to clarify the genetics of other primary headaches. © 1999 Lippincott Williams & Wilkins, Inc.