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Hyperphosphataemia in 2019

have we made progress?

Hutchison, Alastair J.a; Wald, Ronb,c; Hiemstra, Thomas F.d

Current Opinion in Nephrology and Hypertension: September 2019 - Volume 28 - Issue 5 - p 441–447
doi: 10.1097/MNH.0000000000000533
PHARMACOLOGY AND THERAPEUTICS: Edited by Sankar D. Navaneethan
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Purpose of review This review describes recent developments in the management of serum phosphate in dialysis patients, with a focus on the development of recent trials which randomize patients to different levels of control.

Recent findings We review the uncertainties around clinical benefits of serum phosphate control and alternative approaches to current management, as well as a multinational attempt to conduct randomized controlled trials in this area. We discuss novel methods of limiting oral phosphate absorption.

Summary Although numerous guidelines and target ranges for serum phosphate management exist, they are largely based on observational data and there is no definitive evidence that good control improves the length or quality of life of dialysis patients. New phosphate binders continue to appear on the market with increasing financial cost but without additional meaningful outcome data. Two recently published trials have demonstrated the feasibility of a large-scale study of differing phosphate levels to test the hypothesis that reduction of serum phosphate is beneficial to dialysis patients. Restriction of oral phosphate intake should not be overlooked.

aDorset County Hospital, Dorchester, UK

bDepartment of Medicine, St. Michael's Hospital

cDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada

dCambridge Clinical Trials Unit, Cambridge, UK

Correspondence to Alastair J. Hutchison, MBChB, FRCP, MD, Medical Director Trust Headquarters, Dorset County Hospital NHS FT, Williams Avenue, Dorchester DT1 2JY, UK. Tel: +44 1305 254644; e-mail: alastair.hutchison@dchft.nhs.uk

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