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Widening the lens to childhood

relevance and lifetime risk of kidney failure

Rampersad, Christiea; Dart, Allisonb

Current Opinion in Nephrology and Hypertension: May 2019 - Volume 28 - Issue 3 - p 233–237
doi: 10.1097/MNH.0000000000000494

Purpose of review Lifetime risk of outcomes is emerging as a highly relevant health indicator, even in the context of low absolute risk of disease progression in short time frames. Evidence to support this concept for kidney failure is increasing, with growing emphasis on the long-term impact of risk factors occurring early in life.

Recent findings Proteinuria and stage of chronic kidney disease (CKD) are now established predictors of CKD progression in children, and youth with type 2 diabetes are emerging as a group at significant risk. Recent population-based studies have also examined the lifetime risk of end-stage renal disease in individuals with any childhood CKD. A recent study found that even in the absence of biomarkers of renal injury, childhood CKD can increase the lifetime risk of end-stage renal disease four-fold, and up to 10-fold in adults less than 40 years of age.

Summary Children with CKD are at high lifetime risk of kidney failure and require follow-up. Identifying children at highest lifetime risk through the use of biomarkers and risk equations, and determining the optimal duration and intensity of follow-up requires further research.

aDepartment of Internal Medicine

bDepartment of Pediatrics and Child Health, Max Rady College of Medicine, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada

Correspondence to Allison Dart, MD, MSc, FRCPC, Pediatrics and Child Health, Department of Nephrology, FE-009 840 Sherbrook Ave., Winnipeg, MB R3A 1S1, Canada. E-mail:

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