PATHOPHYSIOLOGY OF HYPERTENSION: Edited by Nancy J. BrownNew insights regarding epithelial Na+ channel regulation and its role in the kidney, immune system and vasculatureMutchler, Stephanie M.a,b; Kleyman, Thomas R.a,b,cAuthor Information aDepartment of Medicine bDepartment of Pharmacology and Chemical Biology cDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Correspondence to Thomas R. Kleyman, MD, Renal-Electrolyte Division, A919 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA. E-mail: email@example.com Current Opinion in Nephrology and Hypertension: March 2019 - Volume 28 - Issue 2 - p 113-119 doi: 10.1097/MNH.0000000000000479 Buy Metrics Abstract Purpose of review This review describes recent findings regarding the epithelial Na+ channel (ENaC) and its roles in physiologic and pathophysiologic states. We discuss new insights regarding ENaC's structure, its regulation by various factors, its potential role in hypertension and nephrotic syndrome, and its roles in the immune system and vasculature. Recent findings A recently resolved structure of ENaC provides clues regarding mechanisms of ENaC activation by proteases. The use of amiloride in nephrotic syndrome, and associated complications are discussed. ENaC is expressed in dendritic cells and contributes to immune system activation and increases in blood pressure in response to NaCl. ENaC is expressed in endothelial ENaC and has a role in regulating vascular tone. Summary New findings have emerged regarding ENaC and its role in the kidney, immune system, and vasculature. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.