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The regulation of aldosterone secretion by leptin: implications in obesity-related cardiovascular disease

Faulkner, Jessica, L.; Bruder-Nascimento, Thiago; Belin de Chantemèle, Eric, J.

Current Opinion in Nephrology and Hypertension: March 2018 - Volume 27 - Issue 2 - p 63–69
doi: 10.1097/MNH.0000000000000384
PATHOPHYSIOLOGY OF HYPERTENSION: Edited by Nancy J. Brown
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Purpose of review Although it has been known for some time that increases in body mass enhance aldosterone secretion, particularly in women, the origin of this elevation in aldosterone production is not well defined. Adipocyte-derived factors have emerged as potential candidates to increase aldosterone production in obesity.

Recent findings Emerging evidence suggests the presence of a mechanistic link in which the adipocyte-derived hormone leptin stimulates aldosterone production in obesity, thereby creating a positive feedback loop for obesity-associated cardiovascular disease. In addition, recent reports give credence to the concept that this leptinaldosterone stimulation pathway in obesity is an underlying mechanism for sex-discrepancies in obesity-associated cardiovascular disease.

Summary Leptin appears as a new direct regulator of adrenal aldosterone production and leptin-mediated aldosterone production is a novel candidate mechanism underlying obesity-associated hypertension, particularly in females.

Vascular Biology Center (VBC), Medical College of Georgia at Augusta University, Augusta, Georgia, USA

Correspondence to Eric J. Belin de Chantemèle, Vascular Biology Center (VBC), CB3212B, Medical College of Georgia at Augusta University, 1459 Laney Walker Blvd, Augusta, GA 30912, USA. Tel: +1 706 721 7805; fax: +1 706 721 9799; e-mail: ebelindechanteme@augusta.edu

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