The regulation of aldosterone secretion by leptin: implications in obesity-related cardiovascular diseaseFaulkner, Jessica, L.; Bruder-Nascimento, Thiago; Belin de Chantemèle, Eric, J.Current Opinion in Nephrology and Hypertension: March 2018 - Volume 27 - Issue 2 - p 63–69 doi: 10.1097/MNH.0000000000000384 PATHOPHYSIOLOGY OF HYPERTENSION: Edited by Nancy J. Brown Buy Abstract Author InformationAuthors Article MetricsMetrics Purpose of review Although it has been known for some time that increases in body mass enhance aldosterone secretion, particularly in women, the origin of this elevation in aldosterone production is not well defined. Adipocyte-derived factors have emerged as potential candidates to increase aldosterone production in obesity. Recent findings Emerging evidence suggests the presence of a mechanistic link in which the adipocyte-derived hormone leptin stimulates aldosterone production in obesity, thereby creating a positive feedback loop for obesity-associated cardiovascular disease. In addition, recent reports give credence to the concept that this leptin–aldosterone stimulation pathway in obesity is an underlying mechanism for sex-discrepancies in obesity-associated cardiovascular disease. Summary Leptin appears as a new direct regulator of adrenal aldosterone production and leptin-mediated aldosterone production is a novel candidate mechanism underlying obesity-associated hypertension, particularly in females. Vascular Biology Center (VBC), Medical College of Georgia at Augusta University, Augusta, Georgia, USA Correspondence to Eric J. Belin de Chantemèle, Vascular Biology Center (VBC), CB3212B, Medical College of Georgia at Augusta University, 1459 Laney Walker Blvd, Augusta, GA 30912, USA. Tel: +1 706 721 7805; fax: +1 706 721 9799; e-mail: firstname.lastname@example.org Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.