The kallikrein–kinin system in diabetic kidney disease : Current Opinion in Nephrology and Hypertension

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PHARMACOLOGY AND THERAPEUTICS: Edited by Adam Whaley-Connell and Sankar D. Navaneethan

The kallikrein–kinin system in diabetic kidney disease

Liu, Wenjuana; Stanton, Robert C.b; Zhang, Zhaoyuna,c

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Current Opinion in Nephrology and Hypertension 26(5):p 351-357, September 2017. | DOI: 10.1097/MNH.0000000000000344


Purpose of review 

Diabetic kidney disease (DKD) is one of the most common complications in diabetes mellitus and accounts for a large proportion of clinical nephrology practice. Studies have shown that the kallikrein–kinin system (KKS) may be involved in several pathogenic mechanisms that contribute to DKD, including oxidative stress, inflammatory cytokines, and profibrotic autacoids. This review focuses on recent research advance on the potential role of the KKS in the development of DKD and its clinical relevance.

Recent findings 

A number of recent studies support the idea that there is a protective role of the KKS in diabetes. For example, agents that activate the KKS have shown strong renal protective effects that might highlight its potential to change the clinical practice. In addition, diabetic mice lacking both bradykinin B2 and B1 receptors have worse kidney lesions as compared with wild-type diabetic mice.


Current basic research has demonstrated that pharmacological activation of the KKS improves renal outcomes in diabetes. These findings suggest that this system may be a therapeutic target in preventing and treating DKD.

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

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