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Role of corin in the regulation of blood pressure

Li, Hui; Zhang, Yue; Wu, Qingyu

Current Opinion in Nephrology and Hypertension: March 2017 - Volume 26 - Issue 2 - p 67–73
doi: 10.1097/MNH.0000000000000297
PATHOPHYSIOLOGY OF HYPERTENSION: Edited by Nancy J. Brown
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Purpose of review Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), an important hormone in regulating salt-water balance and blood pressure. This review focuses on the regulation of corin function and potential roles of corin defects in hypertensive, heart, and renal diseases.

Recent findings Proprotein convertase subtilisin/kexin-6 has been identified as a primary enzyme that converts zymogen corin to an active protease. Genetic variants that impair corin intracellular trafficking, cell surface expression, and zymogen activation have been found in patients with hypertension, cardiac hypertrophy, and pre-eclampsia. Reduced corin expression has been detected in animal models of cardiomyopathies and in human failing hearts. Low levels of circulating soluble corin have been reported in patients with heart disease and stroke. Corin, ANP and natriuretic peptide receptor-A mRNAs, and proteins have been colocalized in human renal segments, suggesting a corin-ANP autocrine function in the kidney.

Summary Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease.

aCyrus Tang Hematology Center, MOE Engineering Center of Hematological Disease, and Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China

bMolecular Cardiology, Cleveland Clinic, Cleveland, Ohio, USA

Correspondence to Dr Qingyu Wu, Professor, Department of Molecular Cardiology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Tel: +1 216 444 4351; e-mail: wuq@ccf.org

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