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Calcium channels in primary cilia

Nauli, Surya M.; Pala, Rajasekharreddy; Kleene, Steven J.

Current Opinion in Nephrology and Hypertension: September 2016 - Volume 25 - Issue 5 - p 452–458
doi: 10.1097/MNH.0000000000000251
MOLECULAR CELL BIOLOGY AND PHYSIOLOGY OF SOLUTE TRANSPORT: Edited by Alan S.L. Yu
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Purpose of review Primary cilia have become important organelles implicated in embryonic development, organogenesis, health, and diseases. Although many studies in cell biology have focused on changes in ciliary length or ciliogenesis, the most common readout for evaluating ciliary function is intracellular calcium.

Recent findings Recent tools have allowed us to examine intracellular calcium in more precise locations, that is, the cilioplasm and cytoplasm. Advances in calcium imaging have also allowed us to identify which cilia respond to particular stimuli. Furthermore, direct electrophysiological measurement of ionic currents within a cilium has provided a wealth of information for understanding the sensory roles of primary cilia.

Summary Calcium imaging and direct measurement of calcium currents demonstrate that primary cilia are sensory organelles that house several types of functional calcium channels. Although intracellular calcium now allows a functional readout for primary cilia, discussions on the relative contributions of the several channel types have just begun. Perhaps, all of these calcium channels are required and necessary to differentiate stimuli in different microenvironments.

Department of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, California

Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, Ohio, USA

Correspondence to Surya M. Nauli, Harry and Diane Rinker Health Science Campus, Chapman University, 9401 Jeronimo Road, Irvine, CA 92618-1908, USA. Tel: +1 714 516 5480; fax: +1 714 516 5481; e-mail: nauli@chapman.edu; snauli@uci.edu

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