CIRCULATION AND HEMODYNAMICS: Edited by Roland C. Blantz and Matthew R. WeirRole of immune cells in salt-sensitive hypertension and renal injuryWade, Brittany; Abais-Battad, Justine M.; Mattson, David L.Author Information Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA Correspondence to David L. Mattson, Department of Physiology Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Tel: +1 414 955 8571; fax: +1 414 955 6546; e-mail: [email protected] Current Opinion in Nephrology and Hypertension: January 2016 - Volume 25 - Issue 1 - p 22-27 doi: 10.1097/MNH.0000000000000183 Buy Metrics Abstract Purpose of review Immune mechanisms exacerbate the severity of hypertension in humans and animal models of disease. This review summarizes recent mechanistic studies exploring the pathways whereby immunity influences salt-sensitive hypertension and renal disease. Recent findings Emphasis is placed on the role of T cell subtypes, the mechanisms of T-cell activation, and the identification of potential antigens or neoantigens. Summary Significant advancements have occurred in the search for pathways which activate the adaptive immune response. An enhanced understanding of the factors contributing to hypertension can lead to better therapies. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.