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Novel sensory signaling systems in the kidney

Pluznick, Jennifer L.a; Caplan, Michael J.b

Current Opinion in Nephrology and Hypertension: July 2012 - Volume 21 - Issue 4 - p 404–409
doi: 10.1097/MNH.0b013e328354a6bd
RENAL PATHOPHYSIOLOGY: Edited by Orson W. Moe and Susan Quaggin

Purpose of review This review summarizes recent literature highlighting the roles of chemical and mechanical sensory receptors in renal function.

Recent findings Both chemoreceptors and mechanoreceptors play important roles in renal physiology; here, we discuss specific examples of both chemoreceptors and mechanoreceptors in the kidney.

Summary In order to maintain homeostasis, the kidney uses sensory receptors to assess the composition and rate of flow of the forming urine. Understanding the roles of these receptors will help us to better understand how the kidney functions both in health and in disease.

aDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

bDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA

Correspondence to Michael J. Caplan, Department of Cellular and Molecular Physiology, 333 Cedar St., SHM B-147 Yale University School of Medicine, New Haven, CT 06520, USA. Tel: +1 203 785 7316; fax: +1 203 785 4950; e-mail:

© 2012 Lippincott Williams & Wilkins, Inc.