Pharmacology and therapeutics: Edited by George Bakris and Adam Whaley-ConnellPolypharmacy and medication-related complications in the chronic kidney disease patientMason, Nancy A.a,b Author Information aUniversity of Michigan College of Pharmacy, Ann Arbor bRenal Pharmacy Consultants, LLC, Saline, Michigan, USA Correspondence to Nancy A. Mason, PharmD, Clinical Professor, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, MI 48109-1065, USATel: +1 734 763 4981; fax: +1 734 763 4480; e-mail: [email protected] Current Opinion in Nephrology and Hypertension: September 2011 - Volume 20 - Issue 5 - p 492-497 doi: 10.1097/MNH.0b013e328349c261 Buy Metrics Abstract Purpose of review Medication-related problems are very common in patients with chronic kidney disease (CKD). Identification, prevention and management of these problems require a comprehensive, interdisciplinary approach. This article reviews the recent literature regarding medication-related problems in CKD and proposes initiatives for addressing these problems through a structured review process and use of patient-centered adherence-promoting strategies. Recent findings Pharmacist-conducted medication review and intervention programs are successful at identifying and resolving medication-related problems in CKD patients. These programs are associated with a reduction in the number of medications and frequency of hospitalization, and are associated with maintenance of quality of life. However, adherence continues to be a major medication-related problem in CKD care. Summary Structured medication review and assessment of adherence assist in identification and resolution of medication-related problems in CKD. More research is needed on successful methods to improve medication adherence and related health outcomes. © 2011 Lippincott Williams & Wilkins, Inc.