Renal immunology and pathology: Edited by Agnes B. FogoNew insights into the pathogenesis of cellular crescentsSingh, Sunita KSa; Jeansson, Marieb; Quaggin, Susan Ea,b,c,dAuthor Information aDepartment of Medicine, University of Toronto, Canada bSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada cDivision of Nephrology, St. Michael's Hospital, Canada dDepartment of Medicine, University Health Network, Toronto, Ontario, Canada Correspondence to Dr Susan E. Quaggin, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Box # 41, Toronto, ON M5T 3L9, Canada Tel: +1 416 586 4800; fax: +1 416 586 5130; e-mail: Quaggin@lunenfeld.ca Current Opinion in Nephrology and Hypertension: May 2011 - Volume 20 - Issue 3 - p 258-262 doi: 10.1097/MNH.0b013e32834583ec Buy Metrics Abstract Purpose of review This review discusses the recent evidence that intrinsic glomerular cells including podocytes, parietal epithelial cells and progenitor cells within Bowman's capsule contribute to cellular crescents. Recent findings Using a variety of newer molecular markers and lineage tracing experiments, investigators have clearly demonstrated that glomerular cells play a key role in the development and progression of cellular crescents in experimental and human disease. Summary Crescentic glomerulonephritis is associated with significant morbidity and mortality. Current therapies target the immune system. The recent finding that nonimmune cells also play a role in crescent formation highlights the need to identify alternate and complimentary therapeutic strategies. © 2011 Lippincott Williams & Wilkins, Inc.