Epidemiology and prevention: Edited by Chi-yuan HsuBlood pressure goal in chronic kidney disease: what is the evidence?Agarwal, Rajiv Author Information Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA Correspondence to Rajiv Agarwal, MD, Professor of Medicine, Indiana University and VAMC, 1481 West 10th Street, Indianapolis, IN 46202, USA Tel: +1 317 988 2241; fax: +1 317 988 2171; e-mail: [email protected] Current Opinion in Nephrology and Hypertension: May 2011 - Volume 20 - Issue 3 - p 229-232 doi: 10.1097/MNH.0b013e3283454332 Buy Metrics Abstract Purpose of review Most guidelines recommend that seated clinic blood pressure (BP) be targeted to less than 130/80 mmHg in patients with chronic kidney disease (CKD). The evidence underlying these recommendations is the subject of this review. Recent findings The best evidence to target a certain level of BP in patients with CKD comes from randomized trials. Only three trials have prospectively examined the level to which BP should be lowered. These trials conducted exclusively among patients with CKD have demonstrated that compared to a less aggressive BP goal, a BP goal of less than 130/80 mmHg neither saves lives nor protects the kidney or the cardiovascular system. Summary It is reasonable to achieve a goal of less than 140/90 mmHg in most patients with CKD. More aggressive lowering is not firmly supported by current data. Since BP control is important, hypertension therapy should be individualized. Individualization through home BP measurements to diagnose, monitor and treat hypertension appears to be an attractive option. © 2011 Lippincott Williams & Wilkins, Inc.