Epidemiology and prevention: Edited by Chi-yuan HsuSome methodological issues in studying the long-term renal sequelae of acute kidney injuryLiu, Kathleen D; Lo, Lowell; Hsu, Chi-yuanAuthor Information Division of Nephrology, University of California, San Francisco, San Francisco, California, USA Correspondence to Chi-yuan Hsu, MD, MSc, Division of Nephrology, University of California, San Francisco, 521 Parnassus Avenue, C443, P.O. Box 0532, San Francisco, CA 94143-0532, USA Tel: +1 415 353 2379; fax: +1 415 476 3381; e-mail: email@example.com Current Opinion in Nephrology and Hypertension: May 2009 - Volume 18 - Issue 3 - p 241-245 doi: 10.1097/MNH.0b013e328329d0a3 Buy Metrics Abstract There has been great interest recently in better understanding how an episode of acute kidney injury (AKI) affects risk of development or acceleration of chronic kidney disease. This area of epidemiology research presents several methodological challenges that have not been sufficiently discussed in the literature. These are related to the current consensus definitions of AKI; the determination of ‘baseline’ renal function before the AKI episode; and the possibility that observed associations between AKI and future adverse events are confounded by differences in the severity of baseline chronic kidney disease. In this study, we discuss several potential solutions to these problems. Concerted efforts to address these methodological issues will propel research in this field to a higher level. © 2009 Lippincott Williams & Wilkins, Inc.