Circulation and hemodynamics: Edited by Roland C. Blantz and Matthew R. WeirTubuloglomerular feedback mechanisms in nephron segments beyond the macula densaKomlosi, Petera; Bell, Phillip Da; Zhang, Zhi-Rena,b,cAuthor Information aDivision of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA bState-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Harbin Medical University, China cDepartments of Pharmacy and Cardiology, 2nd Affiliated Hospital of Harbin, Harbin, China Correspondence to Peter Komlosi, 173 Ashley Avenue, CRI 211, Charleston, SC 29425, USA Tel: +1 843 792 5350; fax: +1 843 792-5521; e-mail: [email protected] Current Opinion in Nephrology and Hypertension: January 2009 - Volume 18 - Issue 1 - p 57-62 doi: 10.1097/MNH.0b013e32831daf54 Buy Metrics Abstract Purpose of review To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature. Recent findings In addition to the classical contact site between the macula densa plaque and the afferent arteriole, there is accumulating evidence suggesting a functional association between the distal nephron and the vasculature at three distinct additional sites: at the terminal cortical thick ascending limb, at the early distal tubule and also at the connecting tubule segment. The epithelial cells around the macula densa also sense and respond to changes in tubular flow and salt content and may transmit this signal to the adjacent afferent arteriole. Summary There are multiple sites of anatomical and functional contact between the distal nephron and the vasculature supplying the glomerulus, and these may contribute to the regulation of glomerular filtration rate and renal hemodynamics. © 2009 Lippincott Williams & Wilkins, Inc.