Review ArticleCytokines and hormones with anti-inflammatory effects: new tools for therapeutic interventionBaud, Laurent; Fouqueray, Bruno; Bellocq, AgnèsAuthor Information Unité INSERM 489 and Service d'Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, Paris, France Correspondence to Laurent Baud, M.D., Ph.D., Service d'Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France. Tel: +33 1 56 01 79 51; fax: +33 1 56 01 70 03; e-mail: [email protected] Current Opinion in Nephrology and Hypertension: January 2001 - Volume 10 - Issue 1 - p 49-54 Buy Abstract The inflammation that is involved in the development of glomerulonephritis is tightly regulated by the expression of anti-inflammatory factors. These include circulating hormones, such as glucocorticoids, and mediators that are produced by intrinsic cells and infiltrating leucocytes. The present review focuses on these anti-inflammatory factors, summarizing in particular their activities in existing models of glomerulonephritis. In addition, experimental evidence is presented that anti-inflammatory mediators are able to increase glucocorticoid binding or signalling in target cells. These data help to explain the in-vivo efficacy of anti-inflammatory mediators, and offer a promising new avenue for therapeutic intervention. © 2001 Lippincott Williams & Wilkins, Inc.