Review ArticleCytokine cross-talk between tubular epithelial cells and interstitial immunocompetent cellsvan Kooten, Cees; Daha, Mohamed R.Author Information Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands Correspondence to Dr Cees van Kooten, Department of Nephrology, Leiden University Medical Center, Building 1, C3P, Albinusdreef 2, 2333 AA Leiden, The Netherlands Fax: +31 71 524 8118; e-mail: [email protected] Current Opinion in Nephrology and Hypertension: January 2001 - Volume 10 - Issue 1 - p 55-59 Buy Abstract Immunostaining of renal biopsies of patients with interstitial rejection of allografts or other forms of interstitial inflammation has demonstrated the presence of activated T cells and monocytes/macrophages in the tubulointerstitial area. Cytokines that are produced by infiltrating cells are capable of activating tubular epithelial cells. In turn tubular epithelial cells can produce a wide variety of inflammatory mediators, including chemokines, which further regulate cellular influx. Interfering in this cross-talk between tubular epithelial cells and infiltrating cells might provide new options for therapeutic intervention. © 2001 Lippincott Williams & Wilkins, Inc.