Review ArticleCD2-associated protein and the kidneyShaw, Andrey S.a; Miner, Jeffrey H.bAuthor Information aCenter for Immunology and Department of Pathology, and bDepartment of Internal Medicine, Renal Division and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA Correspondence to Andrey S. Shaw, Department of Pathology, Washington University School of Medicine, 660 S. Euclid Ave., Box 8118, St. Louis, MO 63110, USA. Tel: +1 314 362 6311; fax: +1 314 362 8888; e-mail: [email protected] Current Opinion in Nephrology and Hypertension: January 2001 - Volume 10 - Issue 1 - p 19-22 Buy Abstract During the past 3 years there have been significant advances in our understanding of the biology of the glomerular podocyte. In particular, two proteins, CD2-associated protein and nephrin, have been identified as critical podocyte proteins that are both required for normal glomerular filtration. In addition to supporting the idea that the slit diaphragm plays a crucial role in glomerular function, these results suggest novel insights into the pathogenesis of glomerular diseases. The present review addresses these recent advances and discusses the implications of the findings. © 2001 Lippincott Williams & Wilkins, Inc.