Review ArticleWhich calcineurin inhibitor is preferred in renal transplantation: tacrolimus or cyclosporine?Vanrenterghem, Yves F. Ch.Author Information University Hospital Gasthuisberg, B3000 Leuven, Belgium Correspondence to Yves F Ch Vanrenterghem, Department of Nephrology, University Hospital Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium. Tel: +32 16 344580; fax: +32 16 354599; e-mail: firstname.lastname@example.org Current Opinion in Nephrology and Hypertension: November 1999 - Volume 8 - Issue 6 - p 669-674 Buy Abstract Cyclosporine and tacrolimus are potent inhibitors of the calcineurin-dependent cytokine synthesis in activated lymphocytes. In renal transplant patients tacrolimus is more powerful in preventing severe and refractory rejections, even when compared with the new cyclosporine microemulsion formulation. Both drugs are equally nephrotoxic, but tacrolimus induces less hypertension and less pronounced hyperlipidaemia. Especially in some categories of patients, a higher incidence of de-novo diabetes mellitus is seen with tacrolimus therapy. © 1999 Lippincott Williams & Wilkins, Inc.