Article: PDF OnlyMain Ian W.; Atkins, Robert C.Current Opinion in Nephrology and Hypertension: July 1995 - p 354-358 Buy Abstract The fundamental role of cell-mediated immunity in inflammatory disease of the kidney has been established for some time. This review focusses on the recent advances in our understanding of the role of T-cells in the pathogenesis both of glomerulonephritis and interstitial nephritis. In particular, the increasing experimental evidence for a functional role for T-cell in promoting disease intiation and progression is examined. The ever increasing variety T-cell-effector functions and their relevance are also discussed. © Lippincott-Raven Publishers.