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Dietary protein and skeletal health: a review of recent human research

Kerstetter, Jane Ea; Kenny, Anne Mb; Insogna, Karl Lc

doi: 10.1097/MOL.0b013e3283419441
Nutrition and metabolism: Edited by Paul Nestel and Ronald P. Mensink

Purpose of review Both dietary calcium and vitamin D are undoubtedly beneficial to skeletal health. In contrast, despite intense investigation, the impact of dietary protein on calcium metabolism and bone balance remains controversial. A widely held view is that high intakes of animal protein result in increased bone resorption, reduced bone mineral density, and increased fractures because of its ability to generate a high fixed metabolic acid load. The purpose of this review is to present the recent or most important epidemiological and clinical trials in humans that evaluated dietary protein's impact on skeletal health.

Recent findings Many epidemiological studies have found a significant positive relationship between protein intake and bone mass or density. Similarly, isotopic studies in humans have also demonstrated greater calcium retention and absorption by individuals consuming high-protein diets, particularly when the calcium content of the diet was limiting. High-protein intake may positively impact bone health by several mechanisms, including calcium absorption, stimulation of the secretion of insulin-like growth factor-1, and enhancement of lean body mass. The concept that an increase in dietary protein induces a large enough shift in systemic pH to increase osteoclastic bone resorption seems untenable.

Summary Recent epidemiological, isotopic and meta-analysis studies suggest that dietary protein works synergistically with calcium to improve calcium retention and bone metabolism. The recommendation to intentionally restrict dietary protein to improve bone health is unwarranted, and potentially even dangerous to those individuals who consume inadequate protein.

aDepartment of Allied Health Sciences, University of Connecticut, Storrs

bCenter on Aging, MC-5215, University of Connecticut Health Center, Farmington, USA

cYale University Department of Internal Medicine Endocrinology, New Haven, Connecticut, USA

Correspondence to Jane E. Kerstetter, Department of Allied Health Sciences, 358 Mansfield Rd, Box U-2101, University of Connecticut, Storrs, CT 06269-2101, USA Tel: +1 860 486 1996; e-mail:

© 2011 Lippincott Williams & Wilkins, Inc.