^aDepartments of Medicine, Biochemistry and Biophysics

^bDepartments of Medicine and Pediatrics, Cardiovascular Research Institute, University of California Medical Center, San Francisco, California, USA

Correspondence to Mary J. Malloy, MD, Departments of Medicine and Pediatrics, Cardiovascular Research Institute, Rm 252 M, University of California Medical Center, 555 Mission Bay Blvd. South, San Francisco, CA 94158, USA. . Tel: +1 415 476 2754; fax: +1 415 502 5658; e-mail: mary.malloy@ucsf.edu