ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Mohamad Navab and Menno de WintherMeasurement of carotid plaque burdenSpence, J. DavidAuthor Information Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada Correspondence to J. David Spence, CM, MD, FRCPC, FAHA, Professor of Neurology & Clinical Pharmacology, Western University, and Director, Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, 1400 Western Road, London, ON, Canada N6G 2V4. Tel: +1 519 931 5731; fax 1 519 931 5737; e-mail: [email protected] Current Opinion in Lipidology: October 2020 - Volume 31 - Issue 5 - p 291-298 doi: 10.1097/MOL.0000000000000706 Buy Metrics Abstract Purpose of review To describe the uses of measurement of carotid plaque burden, as total plaque area (TPA), total plaque volume (TPV), and vessel wall volume (VWV), which includes plaque burden and wall volume. Recent findings Measurement of plaque burden is useful for risk stratification, research into the genetics and biology of atherosclerosis, for measuring effects of new therapies for atherosclerosis, and for treatment of high-risk patients with severe atherosclerosis. Summary Measurement of plaque burden is far superior to measurement of carotid intima-media thickness (IMT) in many ways, and should replace it. Vessel wall volume can be measured in persons with no plaque as an alternative to IMT. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.