Purpose of review
Chronic consumption of fructose
-containing sugars leads to dyslipidemia
. Apolipoprotein (apo) CIII is strongly associated with elevated levels of triglycerides and cardiovascular disease risk. We reviewed the effects of fructose
consumption on apoCIII levels and the role of apoCIII in fructose
Consumption of fructose
increases circulating apoCIII levels compared with glucose. The more marked effects of fructose
compared with glucose on apoCIII concentrations may involve the failure of fructose
consumption to stimulate insulin secretion. The increase in apoCIII levels after fructose
consumption correlates with increased postprandial serum triglyceride. Further, RNA interference of apoCIII prevents fructose
in nonhuman primates. Increases in postprandial apoCIII after fructose
, but not glucose consumption, are positively associated with elevated triglycerides in large triglyceride-rich lipoproteins and increased small dense LDL levels.
ApoCIII might be causal in the lipid dysregulation observed after consumption of fructose
-containing sugars. Decreased consumption of fructose
-containing sugars could be an effective strategy for reducing circulating apoCIII and subsequently lowering triglyceride levels.