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Apolipoprotein M/sphingosine-1-phosphate

novel effects on lipids, inflammation and kidney biology

Bisgaard, Line S.a; Christoffersen, Christinaa,b,c

Current Opinion in Lipidology: June 2019 - Volume 30 - Issue 3 - p 212–217
doi: 10.1097/MOL.0000000000000606
LIPID METABOLISM: Edited by Marit Westerterp and Bart van de Sluis

Purpose of review In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest.

Recent findings Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy).

Summary Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.

aDepartment of Clinical Biochemistry, Rigshospitalet

bDepartment of Clinical Biochemistry, Bispebjerg Hospital

cDepartment of Biomedical Science, University of Copenhagen, Copenhagen, Denmark

Correspondence to Christina Christoffersen, Department of Clinical Biochemistry, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark. Tel: +45 35 45 30 11; e-mail:

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