Hyperlipidaemia and cardiovascular disease: Edited by Paul N. DurringtonGlycation as an atherogenic modification of LDLYounis, Nahlaa; Sharma, Reenab; Soran, Handreanb; Charlton-Menys, Valentineb; Elseweidy, Mohameda; Durrington, Paul NbAuthor Information aDepartment of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt bCardiovascular Research Group, School of Clinical and Laboratory Sciences, University of Manchester, Manchester, UK Correspondence to Professor Paul N. Durrington, Cardiovascular Research Group, School of Clinical & Laboratory Sciences, Core Technology Facility (3rd Floor), University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK Tel: +44 161 275 1200/1; fax: +44 161 275 1183; e-mail: [email protected] Current Opinion in Lipidology: August 2008 - Volume 19 - Issue 4 - p 378-384 doi: 10.1097/MOL.0b013e328306a057 Buy Metrics Abstract Purpose of review To highlight the potential importance of glycation as an atherogenic modification of LDL in both diabetic and nondiabetic people. Recent findings Small dense LDL which is known to be most closely associated with atherogenesis is more susceptible to glycation than more buoyant LDL. Glycation and oxidation of LDL appear to be intimately associated. Summary Glycation of LDL occurs chiefly due to the nonenzymatic reaction of glucose and its metabolites with the free amino groups of lysine in which LDL is rich. Higher concentrations of glycated LDL are present in diabetic than in nondiabetic individuals, but even in the latter, there is generally more circulating glycated LDL than oxidatively modified LDL. Probably, oxidation and glycation of LDL are at least partially interdependent, but both prevent LDL receptor-mediated uptake and promote macrophage scavenger receptor uptake. The recognition that LDL glycation is at least as important as oxidation in atherogenesis may lead to improvements in our understanding of its mechanism and how to prevent it. © 2008 Lippincott Williams & Wilkins, Inc.