Nutrition and metabolismLipidomics and lipid profiling in metabolomicsGerman, J Brucea; Gillies, Laura Aa; Smilowitz, Jennifer Ta; Zivkovic, Angela Ma; Watkins, Steven Mb Author Information aDepartment of Food Science and Technology, University of California, Davis, USA bLipomics Technologies, 3410 Industrial Boulevard, West Sacramento, California, USA Correspondence to J. Bruce German, Department of Food Science and Technology, University of California, Davis, CA 95616, USA Tel: +1 530 752 1486; fax: +1 530 752 4759; e-mail: [email protected] Current Opinion in Lipidology: February 2007 - Volume 18 - Issue 1 - p 66-71 doi: 10.1097/MOL.0b013e328012d911 Buy Metrics Abstract Purpose of review The field of metabolomics is extending the principles of genomics into cellular and organism metabolism and driving a revolution in lipid biochemistry, physiology and nutrition. Lipids studied using metabolomic approaches – lipidomics – are an ideal subject for metabolomic measurements. Recent findings Lipids are small molecules that share common physical and chemical properties as a class, whose presence and abundance are key to much of metabolic regulation, from subcellular compartments to whole body energy control and signaling. Furthermore, by measuring changes in lipid concentrations, scientists are gaining a more detailed understanding of biochemistry and thus annotating genomes, but also understanding genetic polymorphisms and the postgenetic effects induced by drugs, foods and toxins. Summary Although in its infancy – there are fewer than 200 total articles on lipidomics and metabolomics focusing on lipids – the field of metabolomics is beginning to deliver on its promise to revolutionize lipid and metabolic disease research. © 2007 Lippincott Williams & Wilkins, Inc.