Atherosclerosis: cell biology and lipoproteinsRegulatory T cell responses: potential role in the control of atherosclerosisMallat, Ziad; Ait-Oufella, Hafid; Tedgui, AlainAuthor Information Institut National de la Santé et de la Recherche Médicale, Inserm U689, Cardiovascular Research Center Lariboisière, and University Paris 7, Paris, France Correspondence to Ziad Mallat, MD, PhD, Inserm U689, 41 bd. de la Chapelle, 75475 Paris cedex 10, France Tel: +33 1 4463 1867; fax: +33 1 4281 3128; e-mail: [email protected] Z.M. is supported by a Contrat d'Interface from Assistance Publique-Hôpitaux de Paris and H.A. is supported by the Fédération Française de Cardiologie. Current Opinion in Lipidology: October 2005 - Volume 16 - Issue 5 - p 518-524 doi: 10.1097/01.mol.0000182532.11512.90 Buy Metrics Abstract Purpose of review Atherosclerosis is an inflammatory disease of the arterial wall where both innate and adaptive Th1-driven immunoinflammatory responses contribute to disease development. Th2-related responses have been shown to be either protective or pathogenic. Thus, it is unclear whether immunoregulatory activity can modulate disease development. Recent findings Novel subtypes of T cells, called the regulatory T cells, have been shown recently to play a critical role in the maintenance of immunological tolerance against self and non-self antigens and prevent the development of various immunoinflammatory diseases. Preliminary studies suggest a potential role for this type of regulatory T cell response in atherosclerosis. Summary Here we present a novel view of the immunoinflammatory response in atherosclerosis where natural and/or adaptive regulatory T cell responses modulate both Th1 and Th2 pathogenic responses and play a central role in counteracting disease initiation and progression. © 2005 Lippincott Williams & Wilkins, Inc.