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Regulation of fatty acid transport

Kalant, David; Cianflone, Katherine

Current Opinion in Lipidology: June 2004 - Volume 15 - Issue 3 - p 309-314
Lipid metabolism
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Purpose of review The aim of the present review is to summarize recent developments in the area of regulation of fatty acid transport.

Recent findings While controversy still exists regarding the contribution of passive diffusion versus protein-mediated fatty acid transport, both processes are now widely accepted. With the recent identification of an increasing number of putative fatty acid transporters, emphasis has been placed on regulation including fatty acid transport function of the protein, and also possible associated functions (acylCoA synthase activity and vectorial channelling to intracellular processing). Deciphering these issues has been facilitated through the use of loss-of-function (such as knockout) and gain-of-function (cell transfectants and transgenic mice) models.

Summary It is likely that our concept of fatty acid transport will continue to converge, incorporating the individual functions of the wide variety of fatty acid transporters into an integrated physiologic framework with relevance to a number of diseases.

Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Canada

Correspondence to Katherine Cianflone PhD, Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1 Tel: +1 514 8421231 ext 35426; fax: +1 514 843 2843; e-mail: katherine.cianflone@mcgill.ca

© 2004 Lippincott Williams & Wilkins, Inc.