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DiCorleto Paul E.; Soyombo, Abigail A.
Current Opinion in Lipidology: October 1993
Atherosclerosis: cell biology and lipoproteins: PDF Only

The endothelium overlies the developing atherosclerotic lesion and we have hypothesized that the endothelial cell (EC) may actively participate in the disease process. In response to stimuli that remain to be rigorously defined, EC may suppress functions that are important for vessel wall homeostasis and induce functions that initiate and maintain atherosclerotic plaque formation. These pro-atherogenic functions of activated or injured EC are discussed, as well as current knowledge about the initiating factors responsible for EC dysfunction, and the potential of the activated EC as a therapeutic target.

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